Sonification Aesthetics and Listening for Network Situational Awareness

This paper looks at the problem of using sonification to enable network administrators to maintaining situational awareness about their network environment. Network environments generate a lot of data and the need for continuous monitoring means that sonification systems must be designed in such a way as to maximise acceptance while minimising annoyance and listener fatigue. It will be argued that solutions based on the concept of the soundscape offer an ecological advantage over other sonification designs.Comment: Workshop paper presented at SoniHED --- Conference on Sonification of Health and Environmental Data, York, UK, 12 September, 201

Genome-wide association study of leprosy in Malawi and Mali

Leprosy is a chronic infection of the skin and peripheral nerves caused by Mycobacterium leprae. Despite recent improvements in disease control, leprosy remains an important cause of infectious disability globally. Large-scale genetic association studies in Chinese, Vietnamese and Indian populations have identified over 30 susceptibility loci for leprosy. There is a significant burden of leprosy in Africa, however it is uncertain whether the findings of published genetic association studies are generalizable to African populations. To address this, we conducted a genome-wide association study (GWAS) of leprosy in Malawian (327 cases, 436 controls) and Malian (247 cases, 368 controls) individuals. In that analysis, we replicated four risk loci previously reported in China, Vietnam and India; MHC Class I and II, LACC1 and SLC29A3. We further identified a novel leprosy susceptibility locus at 10q24 (rs2015583; combined p = 8.81 × 10-9; OR = 0.51 [95% CI 0.40 - 0.64]). Using publicly-available data we characterise regulatory activity at this locus, identifying ACTR1A as a candidate mediator of leprosy risk. This locus shows evidence of recent positive selection and demonstrates pleiotropy with established risk loci for inflammatory bowel disease and childhood-onset asthma. A shared genetic architecture for leprosy and inflammatory bowel disease has been previously described. We expand on this, strengthening the hypothesis that selection pressure driven by leprosy has shaped the evolution of autoimmune and atopic disease in modern populations. More broadly, our data highlights the importance of defining the genetic architecture of disease across genetically diverse populations, and that disease insights derived from GWAS in one population may not translate to all affected populations

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

This work was supported by the Medical Research Council (MR/M004716/1 and MR/N01121X/1 to J.B.) and by Kidney Research UK (RP9/2013 to J.B.). D.C. is supported by the Institute Pasteur, Fondazione Cenci Bolognetti. C.M. is supported by the British Hearth Foundation Fellowship (FS/12/3829640)

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook the largest genome-wide association study of PSC (4,796 cases and 19,955 population controls) and identified four new genome-wide significant loci. The most associated SNP at one locus affects splicing and expression of UBASH3A, with the protective allele (C) predicted to cause nonstop-mediated mRNA decay and lower expression of UBASH3A. Further analyses based on common variants suggested that the genome-wide genetic correlation (rG) between PSC and ulcerative colitis (UC) (rG = 0.29) was significantly greater than that between PSC and Crohn's disease (CD) (rG = 0.04) (P = 2.55 × 10-15). UC and CD were genetically more similar to each other (rG = 0.56) than either was to PSC (P < 1.0 × 10-15). Our study represents a substantial advance in understanding of the genetics of PSC

Sonification of a Network's Self-Organized Criticality for Real-time Situational Awareness

Communication networks involve the transmission and reception of large volumes of data. Research indicates that network traffic volumes will continue to increase. These traffic volumes will be unprecedented and the behaviour of global information infrastructures when dealing with these data volumes is unknown. It has been shown that complex systems (including computer networks) exhibit self organized criticality under certain conditions. Given the possibility in such systems of a sudden and spontaneous system reset the development of techniques to inform system administrators of this behavior could be beneficial. This article focuses on the combination of two dissimilar research concepts, namely sonification (a form of auditory display) and self organized criticality (SOC). A system is described that sonifies in real time an information infrastructure's self organized criticality to alert the network administrators of both normal and abnormal network traffic and operation. It is shown how the system makes changes in a system's SOC readily perceptible. Implications for how such a system may support real-time situational awareness and post-hoc incident analysis are discussed

Association statistics for imputed classical HLA alleles and leprosy risk in Malawi and Mali

Association statistics for imputed classical HLA alleles and leprosy risk in Malawi and Mali

Replication of previously-published leprosy associated non-HLA SNPs in Malawi and Mali stratified by multibacillary and paucibacillary disease

Replication of previously-published leprosy associated non-HLA SNPs in Malawi and Mali stratified by multibacillary and paucibacillary disease

Replication of previously-published leprosy associated non-HLA SNPs in Malawi and Mali

Replication of previously-published leprosy associated non-HLA SNPs in Malawi and Mali